European Pain School®

at the University of Siena

European Pain School®

at the University of Siena

EPS 2024 • Pain and the Immune System

Siena | Italy • 9-15 June 2024

Pain and the Immune System

Siena | Italy • 9-15 June 2024

Programme

Ln Faculty Lectures (L1-L17)
Sn Scholars’ Oral Presentations (S1-S22)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W3)

  • Sunday, 9 June

    11:00-17:00 Arrival of Scholars and Faculty at the Certosa di Pontignano and accommodations
    15:00 Guided tour of Certosa by Giancarlo Carli
    17:00 Welcome greetings by Anna Maria Aloisi
    17:30-18:30 Opening lecture L1. Mike Salter (Toronto, Canada)
    Neuro-immune interactions and pain
    20:00 Dinner
  • Monday, 10 June

    8:00 Breakfast
    9:00-10:00 L2. Camilla Svensson (Stockholm, Sweden)
    Adaptive immune system, autoimmunity and pain
    10:00-10:20 S1. Alexander Rosenström (Uppsala, Sweden)
    Proteins in cerebrospinal fluid and chronic pain – a clinical overview
    10:20-10:40 S2. Livia Steenken (Mainz, Germany)
    Prevalence of chronic widespread pain in multiple sclerosis depending on different immunomodulatory therapies
    10:40-11:00 Coffee break
    11:00-11:20 S3. Karolina Bretova (Brno, Czech Republic)
    Molecular alterations of Cx43 and AQP4 in subpial astrocytes of the medial prefrontal cortex following early periods of sciatic nerve compression
    11:20-11:40 S4. Katarzyna Ciapała (Krakow, Poland)
    Analgesic effects of different intracellular pathways modulators and their influence on opioid analgesia in a mouse model of neuropathic pain
    11:40-12:40 L3. Mike Salter (Toronto, Canada)
    Sex and pain: it’s not always about the differences
    13:00-15:00 Lunch
    15:00-16:00 L4. Camilla Svensson (Stockholm, Sweden)
    Deciphering pronociceptive roles of autoantibodies
    16:00-16:20 S5. Andrea Maria Morace (Naples, Italy)
    Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology and pain implications
    16:20-17:00 Coffee break
    17:00-17:20 S6. Katarzyna Pawlik-Szczerba (Krakow, Poland)
    Modulation of CC chemokine receptor type 1 and type 3 decreases neuropathic pain symptoms through differential effects on microglia/macrophages and neutrophils
    17:20-18:20 L5. Emanuele Sher (Eli Lilly, United Kingdom)
    Central microglia targets for chronic pain treatment (industrial perspective)
    20:00 Dinner
    After dinner W1. Workshop: Debate Teams
  • Tuesday, 11 June

    8:00 Breakfast
    9:00-10:00 L6. Carlo V. Bellieni (Siena, Italy)
    Ethics in pain
    10:00-10:20 S7. Sofia Passaponti (Siena, Italy)
    Development of a cellular model for the study of the ZFHX2 gene involved in pain insensitivity
    10:20-10:40 S8. Valeria Minascurta (Bucharest, Romania)
    Nonpharmacological pain management in elderly patients with knee or hip osteoarthritis
    10:40-11:00 Coffee break
    11:00-11:20 S9. Avgustina Kuzminova (Brussels, Belgium)
    Multisensory interactions between nociception and vision through the looking glass
    11:20-11:40 S10. Elisa Bellantoni (Florence, Italy)
    Oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) is involved in Zebrafish larvae Oxaliplatin-induced painful neuropathy
    11:40-12:40 L7. Emanuele Sher (Eli Lilly, United Kingdom)
    Peripheral macrophage targets for chronic pain treatment (industrial perspective)
    13:00-15:00 Lunch
    15:00-16:00 L8. Shafaq Sikandar (London, United Kingdom)
    Modelling musculoskeletal pain in mice
    16:00-16:20 S11. Katrina Hamilton (Baltimore, MD, USA)
    Assessing cellular aging in chronic musculoskeletal pain and sleep
    16:20-17:00 Coffee break
    17:00-17:20 S12. Raphaël Vincent (Montreal, QC, Canada)
    Health care providers can use telemedicine to diagnose and manage patients with musculoskeletal disorders: a systematic review with meta-analyses
    17:20-17:40 S13. Jolanta Sułek (Zakopane, Poland)
    Determinants of pain in adolescents after surgical treatment of lateral idiopathic curvature of the spine
    17:40-18:00 S14. Niina Jalava (Turku, Finland)
    Inhibition of canonical Transient Receptor Potential Channels 4/5 with highly selective and potent small-molecule HC-070 alleviates mechanical hypersensitivity in rat models of visceral and neuropathic pain
    18:00-19:00 L9. Shafaq Sikandar (London, United Kingdom)
    The immunological basis of pain in fibromyalgia
    20:00 Dinner
    After dinner W2. Workshop: Ugo Basile Srl, Gemonio, Italy
  • Wednesday, 12 June

    8:00 Breakfast
    9:00-10:00 L10. Nurcan Üçeyler (Würzburg, Germany)
    Pain in inflammatory neuropathies
    10:00-10:20 S15. Paola Pacifico (Chicago, IL, USA)
    Epidermal Langerhans cells promote Painful Diabetic Neuropathy through neuroimmune-mediated mechanisms
    10:20-10:40 S16. Gentry Totta-Griese (Kansas City, KS, USA)
    Methylglyoxal, a noxious metabolite, drives nociceptive axon loss in the skin and immune susceptibility
    10:40-11:00 Coffee break
    11:00-11:30 DUETTO: Emanuele Sher and Camilla Svensson
    11:30-12:30 L11. Nurcan Üçeyler (Würzburg, Germany)
    Local and systemic inflammatory mediators in the pathophysiology of neuropathic pain
    13:00-15:00 Lunch
    15:00 Excursion to Montalcino and Bagno Vignoni and Dinner
  • Thursday, 13 June

    8:00 Breakfast
    9:00-10:00 L12. Niels Eijkelkamp (Utrecht, Netherlands)
    Crosstalk between immune cells and sensory neurons in chronic pain conditions
    10:00-10:20 S17. Hla Sudan (Siena, Italy)
    Role of exosomes derived from intestinal cells in the pathogenesis of neurodegenerative diseases
    10:20-10:40 S18. Gabriel Lucena Silva (Ribeirão Preto, Brazil)
    Interleukin 33 derived from mesenchymal cells of the sciatic nerve helps in the differentiation of macrophages and dendritic cells derived from monocytes, leading to the maintenance of nerve degeneration
    10:40-11:00 Coffee break
    11:00-11:20 S19. Silvia Oggero (London, United Kingdom)
    Imbalance of pro-resolving lipid mediator synthesis in macrophages exacerbates persistent inflammatory pain
    11:20-11:40 S20. Jessie Alfaro (San Antonio, TX, USA)
    Identification of trigeminal sensory neurons innervating the temporomandibular joint
    11:40-12:40 L13. Niels Eijkelkamp (Utrecht, Netherlands)
    A transfer of power: how macrophages control pain
    13:00-15:00 Lunch
    15:00-16:00 L14. Thiago Cunha (Ribeirão Preto, Brazil)
    Targeting neuroimmune interaction in neuropathic pain for drug discovery
    16:00-16:20 S21. Nare Navasardyan (Oporto, Portugal)
    Back pain recall in generation XXI adolescents: impact of physical and psycho-social factors
    16:20-17:00 Coffee break
    17:00-18:00 L15. Thiago Cunha (Ribeirão Preto, Brazil)
    Role of meningeal immune cells for neuropathic pain development
    18:00-18:20 S22. Ilenia Casini (Siena, Italy)
    Exploration of the relationship between nutrition and chronic pain
    18:20 W3. Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel)
    Quantitative Sensory Testing (QST): from small fibers to central pain processing (Recruitment of volunteers for 'after dinner' Pain Labs)
    20:00 Dinner
    After dinner W3 Pain Labs:  Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel) and Peter Reeh (Erlangen, Germany)
    Thermode stimulation, QST, neurogenic inflammation (histamine iontopheresis), local anesthesia, primary hyperalgesia
  • Friday, 14 June

    8:00 Breakfast
    9:00-10:00 L16. Fabrizio Benedetti (Turin, Italy)
    The placebo effect: how pain is modulated by psychosocial factors
    10:00-11:00 L17. Fabrizio Benedetti (Turin, Italy)
    The nocebo effect: how pain is generated from nothing
    11:00-11:30 Coffee break
    11:30-12:00 Debate
    The immune and nervous systems act together to produce pain. YES or NO?
    12:00 Closing remarks
    13:00-15:00 Lunch
    15:00-19:00 Guided Visit to Siena
    20:00 Farewell dinner
  • Saturday, 15 June

    Departures