European Pain School®
at the University of Siena
Ln Faculty Lectures (L1-L17)
Sn Scholars’ Oral Presentations (S1-S22)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W3)
Sunday, 9 June |
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| 11:00-17:00 | Arrival of Scholars and Faculty at the Certosa di Pontignano and accommodations |
| 15:00 | Guided tour of Certosa by Giancarlo Carli |
| 17:00 | Welcome greetings by Anna Maria Aloisi |
| 17:30-18:30 | Opening lecture L1. Mike Salter (Toronto, Canada) Neuro-immune interactions and pain |
| 20:00 | Dinner |
Monday, 10 June |
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| 8:00 | Breakfast |
| 9:00-10:00 | L2. Camilla Svensson (Stockholm, Sweden) Adaptive immune system, autoimmunity and pain |
| 10:00-10:20 | S1. Alexander Rosenström (Uppsala, Sweden) Proteins in cerebrospinal fluid and chronic pain – a clinical overview |
| 10:20-10:40 | S2. Livia Steenken (Mainz, Germany) Prevalence of chronic widespread pain in multiple sclerosis depending on different immunomodulatory therapies |
| 10:40-11:00 | Coffee break |
| 11:00-11:20 | S3. Karolina Bretova (Brno, Czech Republic) Molecular alterations of Cx43 and AQP4 in subpial astrocytes of the medial prefrontal cortex following early periods of sciatic nerve compression |
| 11:20-11:40 | S4. Katarzyna Ciapała (Krakow, Poland) Analgesic effects of different intracellular pathways modulators and their influence on opioid analgesia in a mouse model of neuropathic pain |
| 11:40-12:40 | L3. Mike Salter (Toronto, Canada) Sex and pain: it’s not always about the differences |
| 13:00-15:00 | Lunch |
| 15:00-16:00 | L4. Camilla Svensson (Stockholm, Sweden) Deciphering pronociceptive roles of autoantibodies |
| 16:00-16:20 | S5. Andrea Maria Morace (Naples, Italy) Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology and pain implications |
| 16:20-17:00 | Coffee break |
| 17:00-17:20 | S6. Katarzyna Pawlik-Szczerba (Krakow, Poland) Modulation of CC chemokine receptor type 1 and type 3 decreases neuropathic pain symptoms through differential effects on microglia/macrophages and neutrophils |
| 17:20-18:20 | L5. Emanuele Sher (Eli Lilly, United Kingdom) Central microglia targets for chronic pain treatment (industrial perspective) |
| 20:00 | Dinner |
| After dinner | W1. Workshop: Debate Teams |
Tuesday, 11 June |
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| 8:00 | Breakfast |
| 9:00-10:00 | L6. Carlo V. Bellieni (Siena, Italy) Ethics in pain |
| 10:00-10:20 | S7. Sofia Passaponti (Siena, Italy) Development of a cellular model for the study of the ZFHX2 gene involved in pain insensitivity |
| 10:20-10:40 | S8. Valeria Minascurta (Bucharest, Romania) Nonpharmacological pain management in elderly patients with knee or hip osteoarthritis |
| 10:40-11:00 | Coffee break |
| 11:00-11:20 | S9. Avgustina Kuzminova (Brussels, Belgium) Multisensory interactions between nociception and vision through the looking glass |
| 11:20-11:40 | S10. Elisa Bellantoni (Florence, Italy) Oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) is involved in Zebrafish larvae Oxaliplatin-induced painful neuropathy |
| 11:40-12:40 | L7. Emanuele Sher (Eli Lilly, United Kingdom) Peripheral macrophage targets for chronic pain treatment (industrial perspective) |
| 13:00-15:00 | Lunch |
| 15:00-16:00 | L8. Shafaq Sikandar (London, United Kingdom) Modelling musculoskeletal pain in mice |
| 16:00-16:20 | S11. Katrina Hamilton (Baltimore, MD, USA) Assessing cellular aging in chronic musculoskeletal pain and sleep |
| 16:20-17:00 | Coffee break |
| 17:00-17:20 | S12. Raphaël Vincent (Montreal, QC, Canada) Health care providers can use telemedicine to diagnose and manage patients with musculoskeletal disorders: a systematic review with meta-analyses |
| 17:20-17:40 | S13. Jolanta Sułek (Zakopane, Poland) Determinants of pain in adolescents after surgical treatment of lateral idiopathic curvature of the spine |
| 17:40-18:00 | S14. Niina Jalava (Turku, Finland) Inhibition of canonical Transient Receptor Potential Channels 4/5 with highly selective and potent small-molecule HC-070 alleviates mechanical hypersensitivity in rat models of visceral and neuropathic pain |
| 18:00-19:00 | L9. Shafaq Sikandar (London, United Kingdom) The immunological basis of pain in fibromyalgia |
| 20:00 | Dinner |
| After dinner | W2. Workshop: Ugo Basile Srl, Gemonio, Italy |
Wednesday, 12 June |
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| 8:00 | Breakfast |
| 9:00-10:00 | L10. Nurcan Üçeyler (Würzburg, Germany) Pain in inflammatory neuropathies |
| 10:00-10:20 | S15. Paola Pacifico (Chicago, IL, USA) Epidermal Langerhans cells promote Painful Diabetic Neuropathy through neuroimmune-mediated mechanisms |
| 10:20-10:40 | S16. Gentry Totta-Griese (Kansas City, KS, USA) Methylglyoxal, a noxious metabolite, drives nociceptive axon loss in the skin and immune susceptibility |
| 10:40-11:00 | Coffee break |
| 11:00-11:30 | DUETTO: Emanuele Sher and Camilla Svensson |
| 11:30-12:30 | L11. Nurcan Üçeyler (Würzburg, Germany) Local and systemic inflammatory mediators in the pathophysiology of neuropathic pain |
| 13:00-15:00 | Lunch |
| 15:00 | Excursion to Montalcino and Bagno Vignoni and Dinner |
Thursday, 13 June |
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| 8:00 | Breakfast |
| 9:00-10:00 | L12. Niels Eijkelkamp (Utrecht, Netherlands) Crosstalk between immune cells and sensory neurons in chronic pain conditions |
| 10:00-10:20 | S17. Hla Sudan (Siena, Italy) Role of exosomes derived from intestinal cells in the pathogenesis of neurodegenerative diseases |
| 10:20-10:40 | S18. Gabriel Lucena Silva (Ribeirão Preto, Brazil) Interleukin 33 derived from mesenchymal cells of the sciatic nerve helps in the differentiation of macrophages and dendritic cells derived from monocytes, leading to the maintenance of nerve degeneration |
| 10:40-11:00 | Coffee break |
| 11:00-11:20 | S19. Silvia Oggero (London, United Kingdom) Imbalance of pro-resolving lipid mediator synthesis in macrophages exacerbates persistent inflammatory pain |
| 11:20-11:40 | S20. Jessie Alfaro (San Antonio, TX, USA) Identification of trigeminal sensory neurons innervating the temporomandibular joint |
| 11:40-12:40 | L13. Niels Eijkelkamp (Utrecht, Netherlands) A transfer of power: how macrophages control pain |
| 13:00-15:00 | Lunch |
| 15:00-16:00 | L14. Thiago Cunha (Ribeirão Preto, Brazil) Targeting neuroimmune interaction in neuropathic pain for drug discovery |
| 16:00-16:20 | S21. Nare Navasardyan (Oporto, Portugal) Back pain recall in generation XXI adolescents: impact of physical and psycho-social factors |
| 16:20-17:00 | Coffee break |
| 17:00-18:00 | L15. Thiago Cunha (Ribeirão Preto, Brazil) Role of meningeal immune cells for neuropathic pain development |
| 18:00-18:20 | S22. Ilenia Casini (Siena, Italy) Exploration of the relationship between nutrition and chronic pain |
| 18:20 | W3. Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel) Quantitative Sensory Testing (QST): from small fibers to central pain processing (Recruitment of volunteers for 'after dinner' Pain Labs) |
| 20:00 | Dinner |
| After dinner | W3 Pain Labs: Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel) and Peter Reeh (Erlangen, Germany) Thermode stimulation, QST, neurogenic inflammation (histamine iontopheresis), local anesthesia, primary hyperalgesia |
Friday, 14 June |
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| 8:00 | Breakfast |
| 9:00-10:00 | L16. Fabrizio Benedetti (Turin, Italy) The placebo effect: how pain is modulated by psychosocial factors |
| 10:00-11:00 | L17. Fabrizio Benedetti (Turin, Italy) The nocebo effect: how pain is generated from nothing |
| 11:00-11:30 | Coffee break |
| 11:30-12:00 | Debate The immune and nervous systems act together to produce pain. YES or NO? |
| 12:00 | Closing remarks |
| 13:00-15:00 | Lunch |
| 15:00-19:00 | Guided Visit to Siena |
| 20:00 | Farewell dinner |
Saturday, 15 June |
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| Departures | |